摘要
目的:探讨尿微量蛋白水平在新生儿缺氧缺血性脑病(Hypoxic ischemic encephalopathy,HIE)合并肾脏损害早期评价中的应用价值及其与HIE病情严重程度的关系。方法:检测47例足月HIE患儿在生后3d内尿β2微球蛋白(β2-M)、尿微量白蛋白(Alb)、血清尿素氮及肌酐水平,并在生后7d内进行HIE临床分度,以同期13例足月正常新生儿为对照组。观察对比病例组和对照组以上指标,并进行相关性分析。结果:HIE组出生后3d内尿β2-M和Alb明显高于对照组(P<0.01);病例组随临床分度的加重,尿β2-M,ALb,逐渐增高(P<0.05);尿β2-M和Alb呈正相关(r=0.5804,P<0.05);尿β2-M、Alb的异常发生率高于血Cr、BUN,其差异有显著性(P<0.05)。结论:对窒息患儿以临床表现为基础,同时监测出生后3d内尿β2-M和Alb,在HIE的临床分度和其合并肾脏功能损害的早期评价中具有一定的应用价值。
Objective ： To investigate the value of urine trace protein in early evaluation of the hypoxic ischemic encephalopathy （ HIE ） combined with renal injury and the relation with HIE severity. Methods ： 47 cases of full-term HIE neonate were tested of urine β2-MG （ 13 2-M ）, urine albumin（Alb ）, serum Cr and BUN within three days postnatal, each case＇s clinical grading was assessed in 7 days postnatal, and 13 healthy neonate in the same period were randomly chosen as control group. Those index were observed and compared between test and control groups, correlation analysis was also carried out. Results： The urine β2-M and Alb in HIE group were significantly higher compared with control group in three days postnatal（P〈0.01 ）. With increase of clinical severity, urine β2-M and Alb gradually increased（P〈 0.05 ）. Urine β2-M and Alb in HIE group were positive correlated（r= 0.580 4, P 〈0.05 ）. The abnormal rate of urine β 2-M, Alb was significant higher than serum Cr, BUN（P 〈0.05 ）. Conclusions： on the base of clinical manifestation of asphyxiated newborns, measurement of urine β2-M and Alb in 3 days postnatal was valuable in early evaluation of the HIE combined with renal injury and distinction of the clinical severity.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2009年第4期483-485,共3页
Journal of Chongqing Medical University
