摘要
目的 :探讨中药黄芪治疗肾病综合征 ( NS)的作用机制。方法 :应用阿霉素静脉注射法建立肾病大鼠模型 ,同时给予黄芪干预治疗 ,三周后 ,观察其对血浆蛋白、血脂及肾血流动力学的影响。结果 :黄芪可以明显提高 NS大鼠血浆白蛋白水平 ,同时使 NS大鼠明显增高的血脂水平恢复到正常范围。廓清试验发现 ,黄芪可明显改善 NS大鼠肾小球滤过率 ( GFR)和尿钠排泄 ( UNa V)。结论
Objective:To explore the mechanism of Chinese herbal medicine Astragalus in treatment of nephrotic syndrome.Method:Nephrotic ratmodel was made by tail vein injection of adriamycin 6 mg/ kg,3 weeks after,Astragalus was given,and changes of phasma protein lipidemia and renal hemodynamics were observed. Results:Itwas shown that plasma protein was significantly increased with significant decrease of lipidemia as compared with those of the normal controls.Clearance test showed thatthe glomerular filtration rate(GFR) and urinary sodium excretion(UNa V) were also significantly increased.Conclusion:The above effects might be the partial mechanism of Astragalus in treatment of nephrotic syndrome.
出处
《上海医学》
CAS
CSCD
北大核心
1998年第3期146-147,共2页
Shanghai Medical Journal
