摘要
白细胞介素17(IL-17)主要由活化的T淋巴细胞产生的促炎性细胞因子发挥免疫调节、促炎症反应、增强滋养细胞浸润性和促进血管新生的作用,在感染性疾病、自身免疫性疾病的免疫病理学中起着重要的作用。人胎盘绒毛滋养细胞、绒毛外滋养细胞和Hofbauer细胞以及鼠蜕膜组织均表达IL-17,而且表达水平呈现动态变化,因此,IL-17可能参与妊娠免疫耐受的调节。对IL-17的研究及其与妊娠和子痫前期的关系作简要综述。
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted exclusively by activated T-cells, plays an important role in immunoloregulation, proinflammatory, regulating trophoblast invasion and angiogenesis o IL-17 is also a host mechanism of immunopathology of infectious diseases and auto-immune disease. IL-17 are expressed in placental trophoblast cells, extravillous trophoblast ceils, and placental macrophages (Hofbauer cells). Moreover, the expression of IL-17 are viable in different phases of pregnancy, IL-17 may involve in immunoregulation in the establishment of pregnancy. In this article, We provide a brief review about interleukin-17 in pregnancy and gestational diseases.
出处
《国际妇产科学杂志》
CAS
2009年第2期140-143,共4页
Journal of International Obstetrics and Gynecology