摘要
研究应用中药肝灵（由叶下珠、黄芪等药物组成）对大鼠急性肝损伤的保护作用。通过观察血清ＡＬＦ活性、总胆红素、ＴＰ、ＡＬｂ，肝组织匀浆ＳＯＤ、ＭＤＡ，红细胞免疫及光镜，探讨肝灵保肝作用的机理。研究表明：肝灵使急性肝损伤大鼠血清ＡＬＴ活性、总胆红素活性降低，使肝组织匀浆ＳＯＤ含量上升，ＭＤＡ含量下降，使红细胞Ｃ３ｂ受体的形成率上升，红细胞ＩＣＲ形成率下降，减轻肝组织的病理损伤程度。其保肝作用机理为：保护肝细胞膜、抗脂质过氧化、促进蛋白合成，调节免疫。
Formulae Gan Ling,Chinese herbal medicine,consists of Ye Xia Zhu,Huang qi,etc ,which can inhibit HBV relication and restore liver function to normal.In order to confirm the effect of the medicine,we studied the effect of Gan Ling protecting liver from injury through rat acute hepatic injury model made by DGlan.The results revealed that Gan Ling could reduce the ALT activity in serum and content of total bilirubin;raise SOD and reduce MDA in liver homogenate;increase the formating rate of RBCC3bRR and lower formating rate of RBCICR;and could abate the degree of hepatic pathological injury.The study indicated that the mechanisms of Gan Ling protecting liver from injury are to protect cellular membrane of liver,to resist lipid peroxidation,to promote protein synthesis and adjust immunity.
出处
《承德医学院学报》
1998年第1期9-11,共3页
Journal of Chengde Medical University
关键词
肝灵
中药
保肝作用
急性肝损伤
疾病模型
Gan ling
Chinese drugs
liverprotective effect
acute hepatic injury model
