摘要
目的:观察伞形科辛味中药主要化学成分对离体血管的舒张作用。方法:采用大鼠离体主动脉环模型,分别观察蛇床子素、阿魏酸钠、积雪草苷、茴香醛、藁本内酯、丁基苯酞、白花前胡丙素、欧前胡素、异欧前胡素、α-细辛醚等10种化合物,对离体血管的舒张作用。结果:蛇床子素、欧前胡素、异欧前胡素、白花前胡丙素、细辛醚、丁基苯酞的舒张血管活性强于川芎嗪,藁本内酯、茴香醛与川芎嗪相当,阿魏酸钠、积雪草苷活性弱于川芎嗪。结论:药典收载的伞形科辛味中药均具有舒张血管作用。
Objective ：To observe the vasorelaxation effect of pungent herbs＇chemical constituents in Umbelliferae. Methods ：The vasorelaxation effect of 10 compounds was observed by isolated vascular rings model . Results ：The results showed that the vasorelaxation effect of 6 compounds （ osthole, imperatorin, isoimperatorin, praeruptorin, asarone, butylphthalide ） were stronger than tetramethylpyrazine. The vasorelaxation effect of ligustilide and anisaldehyde suitable to tetramethylpyrazine. The vasorelaxation effect of fendic acid sodium and asiatieoside were less than tetramethylpyrazine. Conclusion ： vasorelaxation effect is one of the generic pharmacological activity of pungent herbs in Umbelliferae.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2009年第1期38-40,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(30600820)
国家重点基础研究发展计划(2006CB504700)
国家自然科学基金项目(30472143)
关键词
中药药性
伞形科
化学成分
血管活性
Umbelliferae
chemical constituents
vasoactive
generic pharmacological activity
