摘要
目的用Meta分析方法评价超声造影对肝脏肿瘤诊断的价值。方法搜索Pubmed数据库、Embase数据库、Cochrane library、CBM以及CNKI数据库,手工检索所有用超声造影对肝脏肿瘤进行诊断的文献,提取相关文献数据。采用QUADAS工具进行文献的质量评价。采用Meta-disc软件进行数据分析,得到合并的比数比、合并的诊断敏感度和特异度以及合并的阳性和阴性似然比,绘制综合接受者工作特征（SROC）曲线。结果共纳入9个研究,9个研究结果存在异质性（P=0.05,I^2=64.00%）。利用随机效应模型合并的诊断敏感性和特异性分别为91.30%（CI：89.80%-92.70%）和94.00%（CI：92.00%-95.60%）,合并阳性似然比为12.03（CI：7.67-18.88）,合并阴性似然比为0.08（CI：0.08-0.14）,合并比数比为153.00（CI：71.40-327.86）,加权SROC面积为0.93,SE=0.01。结论入选文献质量中等。SROC显示超声造影对肝脏肿瘤有较高的诊断价值。
Objective To assess the value of contrast-enhanced ultrasonography in diagnosis of patients with hepatic neoplasm. Methods Published studies were identified by Pubrned, Embase, CBM, Cochrane library and CNKI to search hepatic neoplasm using contrast-enhanced ultrasonography. The quality of the included studies was assessed using the QUADAS tool. Meta-disc software was used to extract data and to calculate the summary diagnostic odds ratio, summary sensitivity and specificity, summary positive likelihood ratio and summary negative likelihood ratio, and the summary receiver operating characteristic （SROC） curve was drawn. Results Nine inconsistent studies （P=0.05, I^2=64.00%） were included. Summary sensitivity and specificity was 91.30% （CI：89.80%-92.70%）, and 94.00% （CI：92.00%-95.60%） respectively; summary positive likelihood ratio was 12. 03 （CI： 7.67-18. 88）, summary negative likelihood ratio was 0.08 （CI： 0.08-0.14） and summary diagnostic odds ratio （random effects model） was 153. 00 （CI： 71.40-327. 86）, while weighted area under curve （AUC） was 0.93, SE=0. 01. Conclusion Nine studies were moderate qualitified. SROC showed that contrastenhanced ultrasonography has a high value in diagnosis of hepatic neoplasm and is a good modality for patients with hepatic neoplasm.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第4期646-649,共4页
Chinese Journal of Medical Imaging Technology
关键词
超声检查
肝肿瘤
诊断
META分析
Ultrasonography
Liver neoplasms
Diagnosis
Mata analysis
