摘要
目的探讨对氧磷酯酶(PON1)L/M55基因多态性与缺血性脑卒中(CAT)的相关性。方法用聚合酶链式反应-限制性长度片断多态性(PCR-RFLP)技术,对143例CAT患者和122例相匹配的正常对照组PON1L/M55基因型及等位基因频率进行检测,并做统计学分析。结果CAT组与对照组PON1L/M55基因多态性的基因型分布分别为LL型85.31%(122/143)、88.52%(108/122);LM型10.49%(15/143)、8.20%(10/122);MM型4.20%(6/143)、3.28%(4/122),CAT组与对照组组间比较三种基因型差异无统计学意义(P>0.05)。结论PON1L/M55基因多态性与缺血性脑卒中的发病无关。
Objective To explore the relationship between the PON1 L/M55 gene polymorphism and cerebral arterial thrombosis （CAT）. Methods A total of 143 CAT patients and 122 control subjects were enrolled in this study for examination of PON1 L/M55 gene polymorphisms by using poIymerise chain reaction - restriction fragment length polymorphism （ PCR - RFLP）. Results The distribution of the PON1 L/M55 polymorphism between CAT patients and control groups was LL genotype： 85.31% （ 122/143）, 88.52% （108/122） ; LM genotype ： 10.49% （ 15/143 ）, 8.20% （10/122） ; MM genotype ： 4.20% （6/143）, 3.28% （4/122）. There were no significant difference for LL, LM, MM genotypes of PON1 L/M55 polymorphism between CAT patients and control groups （P 〉 0. 05）. Conclusion There is no significant association between PON1 L/M55 polymorphism and cerebral arterial thrombosis.
出处
《宁夏医学杂志》
CAS
2009年第4期327-328,F0002,共3页
Ningxia Medical Journal
基金
宁夏科技厅科技攻关项目
