摘要
目的分析山东省痰涂片阳性(涂阳)肺结核(SMPTB)并糖尿病(DM)患者的抗结核药物敏感性,评价糖尿病相关肺结核的流行趋势、临床特点及耐药情况。方法收集2004年10月至2007年10月间在山东省胸科医院住院的3 000例本省肺结核病人的资料,SMPTB 1 700例,其中DM并初治PTB 450例、DM并复治PTB 150例及单纯SMPTB 1 100例,行血糖、结核菌培养及药敏试验检查。结果对1 653例痰结核分枝杆菌培养阳性的菌株进行10种抗结核药物的敏感性测定。其中初治SMPTB并DM患者耐药率为3.6%,复治患者耐药率为79.7%,两者有统计学差异(x^2=360.8,P<0.01)。结论初治涂阳肺结核合并糖尿病患者的耐药率极低,但复治患者耐药率明显增加。
Objective To analyze the sensitivities of antituberculosis drugs of SMPTB with diabetes melltus（PTB/DM） in Shandong for evaluating the PTB epidemic tendency,clinical manifestation and anti- TB drug resistance of PTB/DM. Methods Data of 3000 in-hospital patients in Shandong Provincial Chest Hospital were collected during October 2004 to October 2007. The 1700 cases with SMPTB were divided into initial treatment group with 450 patients and retreatment group with 150 patients and purely SMPTB group with 1100 patients. Blood sugar,mycobacterium tuberculosis cultivation and drug sensitivety tests were pcrformded. Results 1653 SMPTB patients showed positive culture of sputum mycobacterium tuberculosis. The rate of drug fast was 3.6 % in patients of initial treatment SMPTB with DM,but was 79.7% in the retreatment SMPTB/DM patients （x^2 =360.8,P〈0.01）. Conclusions The anti-TB drug resistance is extremly low in initial treatment SMPTB patients with DM, but is obviously increased in retreatment SMPTB/DM patients.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2009年第4期278-280,共3页
Chinese Journal of Diabetes
