摘要
目的探讨毛果芸香碱凝胶（ｐｉｌｏｃａｒｐｉｎｅｇｅｌ，ＰＧ）治疗青光眼是否优于毛果芸香碱水溶液（ｐｉｌｏｃａｒｐｉｎｅｓｏｌｕｔｉｏｎ，ＰＳ）。方法对２０例应用４％ＰＧ每晚１次和２０例应用１％ＰＳ每天４次的青光眼患者进行比较，两组患者均每天４次检查眼压、瞳孔直径和屈光度。结果４％ＰＧ每晚１次有效降眼压时间可持续２４小时，降眼压幅度达２５％～３７％；１％ＰＳ每天４次，降眼压幅度为２０％～２５％。ＰＧ在用药后５～１３小时降眼压作用最强，且９及１１时的作用强于ＰＳ，这对于控制起床前及上午眼压高峰特别有利。ＰＧ引起缩瞳及增强调节的最强作用在用药后５～８小时（睡眠期间），而ＰＳ则在白天引起波动性的缩瞳及近视。ＰＧ每天仅需用药１次，较ＰＳ方便。结论在药效、副作用及依从性方面ＰＧ优于ＰＳ，值得推广、应用。
Objective To evaluate whether pilocarpine gel (PG) is better than pilocarpine solution (PS) for treatment of glaucoma. Methods 20 cases with glaucoma treated with 4% PG once every night were compared with 20 cases with glaucoma using 1% PS 4 times a day. The intraocular pressure (IOP), pupil diameter and refraction were examined 4 times a day in both groups. Results The PG could lower IOP by 25%～37% and the PS by 20%～25%,the hypotensive effect of PG could last 24 hours. The PG had the strongest hypotensive effect 5～13 hours after its application, and a stronger action than PS at 9 a.m. and 11 a.m, this is particularly beneficial for the control of the peak IOP before awaking and in the morning. The strongest action of miosis and accommodation enhancement of PG took place 5～8 hours after its application when the patients were sleeping, whereas the PS induced a fluctuating miosis and myopia in the day time. In addition, the PG was more convenient to be used than PS due to its single application for 24 hours. Conclusion The PG has some advantages in the respects of compliance, lowering IOP and side effects, thus it is worthwhile to promote its manufacture.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
1998年第3期174-177,共4页
Chinese Journal of Ophthalmology
关键词
毛果芸香碱
凝胶类
青光眼
药物疗法
Pilocarpine Gels Miotics Glaucoma Intraocular pressure Pupil Refraction, ocular
