摘要
目的:探讨具有清热利湿、活血化瘀功效的慢前饮对雌激素诱导的大鼠慢性非细菌性前列腺炎的作用疗效和机理。方法:采用雌二醇多点注射的方法制作大鼠慢性非细菌性前列腺炎模型,前列倍喜为阳性药物组,观察慢前饮对非细菌性前列腺炎模型前列腺形态学的影响,以及对促炎症因子TNF-α和前炎症细胞因子IL-8水平的影响。结果:与对照组相比,前列倍喜组和慢前饮组慢性炎症的病理表现明显好转,前列倍喜和慢前饮组的促炎症因子TNF-α均明显降低(P<0.05),前炎症细胞因子IL-8水平也明显降低(P<0.05)。结论:慢前饮降低促炎症因子TNF-α和前炎症细胞因子IL-8水平,并可减轻前列腺组织内炎症反应,减少纤维化程度,缓解尿道平滑肌痉挛,调节前列腺局部免疫功能,是治疗慢性非细菌性前列腺炎的作用机理,祛瘀化湿法可以作为慢性非细菌性前列腺炎的主要治疗方法之一。
Objective ： to study the therapeutic mechanism of Manqianyin prescription which with the function of clearing heat to disperse dampness and removing stagnation to promote circulation on rats with chronic nonbacterial prostatitis. Methods ：Rat model was made by injected estradiol benzoate,Qianlie Beixi capsule as a control group,the prostatic tissue was examined histologically for degree of inflammation, the levels of inflammation factors TNF -α and IL - 8 also were observed. Results ： compare with control group, the pathologic sign of chronic inflammation was relieved significantly, and the levels of inflammation factors TNF-α and IL- 8 lower than control group （P 〈 0. 05 ）. Conclusion：Manqianyin prescription can lower the levels of inflammation factors TNF - α and IL - 8 and relieving the inflammation in rat prostatic tissue. The mechanism of Manqianyin prescription in treating chronic prostatitis can be explained by relaxing urethral smooth muscle, anti prostatic fibrosis, regulating the immune function in prostate, removing stagnation to eliminating damphess can be treated as a main therapeutic method when in treating prostatitis.
出处
《中华中医药学刊》
CAS
2009年第3期512-514,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局科研基金项目(2006C136)
