摘要
目的:观察银杏叶提取物(Ginkgo biloba extract)对脑缺血再灌注大鼠海马一氧化氮(NO)产生的影响。方法:大鼠脑缺血采用四血管阻断法,选择性NO测定电极检测NO的浓度。实验分为生理盐水组和银杏叶提取物组。结果:银杏叶提取物没有影响大鼠的血压和海马的血流量,显著地减少了缺血再灌流时海马内NO的产生(P<0.001)。结论:银杏叶提取物可能通过抑制一氧化氮的产生(NO)而起到神经保护作用。
Objective ： To investigated the effects of Ginkgo biloba extract on nitric oxide （NO） concentration in rat hippocampus after transient forebrain ischemia. Methods ： The model of forebrain ischemia was made by 4 - vessel occlusion for 10min. NO concentration was measured directly by an NO - selective electrode method. Saline and Ginkgo biloba extract was administered intraperitoneally 20 min before the onset of ischemia. Results ： Ginkgo biloba extract did not affect the hippocampal blood flow and mean arterial blood pressure （ MABP）, compared with the saline group, Ginkgo biloba extract significantly reduced the NO production during post -ischemic early reperfusion （ P 〈 0.001 ）. Conclusion： Ginkgo biloba extract has protective effect on hippocampal neurons against cerebral ischemia - reperfusion injury may be by reducing the content of NO in hippocampus of rat.
出处
《中华中医药学刊》
CAS
2009年第1期55-57,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家人事部留学回国人员科技活动择优资助基金项目(2003433)
杭州市科技发展计划医学重点专科专病项目(2005633Q21)
关键词
银杏叶提取物
脑缺血
一氧化氮
Ginkgo biloba extract
forebrain ischemia
nitric oxide
