摘要
目的探讨替米沙坦联合尿毒清颗粒治疗早期糖尿病肾病的临床疗效。方法将64例早期糖尿病肾病(DN)患者随机分为替米沙坦组(对照组)和替米沙坦联合尿毒清颗粒治疗组(治疗组),每组32例。疗程均为6个月。观察2组治疗效果,检测空腹血糖(FBG)、血清总胆固醇(TC)、三酰甘油(TG)、血白蛋白(Alb)、血肌酐(SCr)、尿素氮(BUN)、尿微量白蛋白排泄率(UAER)等变化情况。结果与治疗前比较,治疗组TC、TG明显下降(P<0.05),高密度脂蛋白(HDL)明显上升(P<0.05),对照组上述指标变化不明显(P>0.05)。2组均能显著改善早期DN患者UAER(P<0.05或0.01),而治疗组较对照组疗效显著(P<0.05);治疗组治疗后SCr明显下降(P<0.05),而对照组变化不明显(P>0.05)。2组治疗后FBG、BUN、Alb均无明显变化(P>0.05)。结论替米沙坦联合尿毒清颗粒治疗早期DN疗效确切。
Objective To investigate the therapeutic effects of telmisartan and Niaoduqing pellet in treating early diabetic nepbropathy（DN）. Methods 64 patients with DN were randomly allocated into treatment group and control group, 32 cases per group. Uremic clearance granule was adminisered continuously for 6 months in treatment group in addition to the conventional treatment with telmisartan in control group. Results TC, TG, SCr decreased and HDL-C increased significantly in treatment group after treatment （ P 〈 0.05 ） , but there were no obvious changes in control group （ P 〉 0.05 ）. In both the groups UAER reduced obviously, and there was signicantl differencebetween the two groups （ P 〈 0.05 ）. Comepared to the control group, the reduction of SCr was greater in treatment group （ P 〈 0.05 ）. Meanwhile there was no significant difference in FBG, BUN and Alb before and after treatment in the two groups （ P 〉 0.05 ）. Conclusions The therapeutic effects of Niaoduqing pellet in combination with telmisartan in treating early diabetic nephropathy are definite.
出处
《临床合理用药杂志》
2009年第6期9-10,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
糖尿病
肾病
尿毒清颗粒
替米沙坦
Diabetic nephropathy
Niaoduqing pellet
Telmisantan
