摘要
目的研究高胆红素血症（高胆）新生儿血清S-100蛋白水平和总胆红素（TBC）与白蛋白（B／A）比值的变化，为早期预测胆红素脑损伤提供新的方法。方法根据胎龄、体质量和是否符合黄疸干预标准将出生7d内的84例新生儿分为足月高胆组、足月对照组、早产高胆组、早产对照组。检测4组血清S-100蛋白、TBC、白蛋白水平，计算B／A比值。结果足月高胆组S-100蛋白含量[（0．36±0．14）μg／L]高于足月对照组[（0．25±0．07）μg／L]，差异有显著性（P〈0．05），足月高胆组S-100蛋白含量与B／A比值呈正相关性（r=0．509，P〈0．05）。早产高胆组S-100蛋白含量[（0．4JD±0．09）μg／L）高于早产对照组[（0．28±0．05）μg／L]，差异有显著性（P〈0．05），S-100蛋白含量与B／A比值无相关性（r=0．356，P〉0．05）。结论血清S-100蛋白和B／A比值可作为早期预测胆红素神经毒性的敏感指标。
Objective To evaluate the significance of S-100 protein and B/A for early predicting the brain damage caused by neonatal hyperbilirubinemia. Methods According to the gestational age, birth weight and the intervention criterion of neonatal jaundice,84 newborns were divided into 4 groups. Group A （ n = 22） were term infants with unconjugated hyperbilirubinemia. Group B （ n = 22 ） were control group of term infants. Group C （ n = 20 ） were premature newborns with unconjugated hyperbilirubinemia. Group D （n = 20） were premature control group. We detected their serum levels of S-100, total bilirubin （TBC）, albumin and calculated B/A ratio. Results The S-100 level and B/A ratio of hyperbilirubinemia group were significantly higher than those of control group in term infants [group A（0. 36 ±0. 14） μg/L vs group B （0. 25 ±0. 07） μg/L, P 〈 0. 05） and premature newborns （ group C （ 0. 40 ± 0. 09） μg/L vs group D （ 0. 28 ± 0. 05 ） μg/L, P 〈 13. 05 ） ]. There was positive correlation between level of serum S-100 and B/A ratio in hyperbilirubinemia group of term infants （r =0. 509,P 〈0. 05）. Conclusion Serum S-100 protein and B/A ratio may be a sensitive indicators for early predicting bilirubinic toxicity.
出处
《中国小儿急救医学》
CAS
2009年第2期137-139,共3页
Chinese Pediatric Emergency Medicine
