摘要
目的:研究宁胃康浸膏对消化道运动功能的作用。方法:采用多种动物模型观察宁胃康浸膏对在体和离体胃肠平滑肌运动的影响,并研究其对乙酰胆碱和氯化钡收缩离体肠管作用的影响。结果:宁胃康浸膏可显著减少活性炭在小鼠小肠内的移动距离(P<0.01),可显著降低麻醉家兔的回肠收缩幅度和收缩频率(P<0.05或P<0.01),对乙酰胆碱引致的离体豚鼠回肠痉挛无明显的抑制作用(P>0.05),能显著抑制氯化钡引致的离体豚鼠回肠的痉挛(P<0.05)。结论:宁胃康浸膏能显著抑制胃肠道运动功能,其机制可能与阻滞Ba2+作用有关。
Objective ： To study the effect of Ning Wei Kaug Recipe extract on gastrointestinal motor function. Methods ： The effects of Ning Wei Kang Recipe extract on gastrointestinal motor function were studied in mice, rabbits, and isolated mesenterial intestines of guinea pig according to its effect on acetylcholine or barium chloride-induced contraction. Results ： Ning Wei Kang Recipe extract could significantly decrease the propellent movement of medicine charcoal in the mesenterial intestine of mice（P 〈 0. 01 ）, inhibit the range and speed of mesenterial intestine of rabbits（ P 〈 0. 05, or P 〈 0. 01 ）, relax the contration of isolated mesenterial intestines of guinea pig induced by BaC12 （ P 〈 0. 05 ）. But it could not decrease the contration of isolated mesenterial intestines of guinea pig induced by acetylcholine（P 〈0.05）. Conclusions： Ning Wei Kang Recipe extract can significantly inhibit the gastrointestinal motor function. It may be related to blocking positive ion-Ba^2＋ into gastrointestinal smooth muscle cell.
出处
《中药材》
CAS
CSCD
北大核心
2009年第3期401-403,共3页
Journal of Chinese Medicinal Materials
关键词
宁胃康浸膏
消化道运动
离体回肠
Ning Wei Kang Recipe extract
Gastrointestinal motor function
Isolated mesenterial intestines
