摘要
目的探讨兔严重胸腹伤后早期莫沙必利促肠道动力治疗对肝损伤的影响。方法采用BIM-IV型生物撞击机建立实验性胸腹撞击伤动物模型,将30只新西兰兔随机分为创伤组、创伤促动力组和对照组,观察门静脉血流量、血清总蛋白(TP),白蛋白(ALB),丙氨酸氨基转移酶(ALT),谷草转氨酶(AST)及肝脏大体和镜下病理变化。结果创伤促动力组门静脉血流量下降程度明显较小,血清丙氨酸氨基转移酶(ALT)升高水平低于创伤组,并且肝细胞损害较轻。结论兔严重胸腹伤后早期采用莫沙必利促胃肠道动力治疗对减轻肝脏损害有一定作用。
Objective To evaluate the effects of prokinetics - mosapride on liver injury in New Zealand white rabbits in early stage of severe thoraco-abdominal injury. Methods The experimental model of thoraco-abdominal injury was established. Thirty New Zealand white rabbits were randomly divided into control group, trauma group and mosapride treated group, and portal venous flow, serum TP, ALB, ALT, AST, morphological change of liver were measured. Results The degree of decreasing in portal venous flow and increase in ALT was low- er, and pathological lesion of liver was better in mosapride treated group than that of trauma control group. Conclusion Mosapride is helpful to ease liver injury in the early stage of severe thoraco-abdominal injury.
出处
《局解手术学杂志》
2009年第2期91-93,共3页
Journal of Regional Anatomy and Operative Surgery
关键词
促动力剂
肝损伤
胸腹伤
莫沙必利
prokineties
liver injury
thoraco-abdominal injury
mosapride
