摘要
为探讨细胞凋亡在胆囊肿瘤形成中的作用，我们用原位末端标记法对24例胆囊癌和16例胆囊腺瘤中的凋亡细胞进行测定。结果显示：胆囊腺瘤中的细胞凋亡数低于原发性胆囊癌（P<O．01），高分化及Nevin分期Ⅰ、Ⅱ、Ⅲ期腺癌中的凋亡细胞数低于低分化及Nevin分期IV、V期者（P＜0．05）。因此作者认为细胞凋亡在胆囊癌发病中起重要作用，可以作为预测胆囊癌病程和预后的指标。
<Abatract>in order to investigate the effect of apoptosis in gallbladder neoplasms,the number of the apopototive cell was observed in 24 gallbladder cacinomas and 16 gallbladder neoplasmas,using in situ end labeling(ISEL) method. The number of apopotosis in gallbladder adenoma was significantly lower than in gallbladder carcinoma (P<O. o1 ) ;Well differentiated gallbladder carcinoma had less apopotic cell than poorly differentiated gallbladder carcinoma(p<0. 05). Concl u s ion: Apopo tos is ma y payl an improta nt role in the pa tbogenes is of gall bladder c arc inoma. Apopotosis may be a promising predictor for the prognosis of patients with gallbladder carcinoma.
出处
《肝胆外科杂志》
1998年第2期125-126,共2页
Journal of Hepatobiliary Surgery
关键词
胆囊肿瘤
细胞凋亡
原位末端标记法
Gallbladder neoplasms Apoptosis in situ end labeling(ISEL)
