摘要
目的探讨p53、P-糖蛋白(P-gp)、谷胱甘肽S转移酶(GST-π)和DNA拓扑异构酶Ⅱα(TopoⅡα)在老年消化道肿瘤中的表达及意义。方法对33例老年(≥60岁)消化道肿瘤组织进行p53蛋白、P-gp、GST-π和TopoⅡα免疫组化染色,并以35例(<60岁)消化道肿瘤作为对照。结果老年组患者在临床病理学特征中,高分化腺癌(22/33)、大肠癌(22/33)患者比例明显高于对照组(均P<0.01)。老年组P-gp、GST-π表达明显高于对照组(分别为P=0.009、P=0.026),p53在两组间差异不显著(P=0.293),而TopoⅡα表达则低于对照组(P=0.032)。结论老年消化道肿瘤P-gp和GST-π高表达、TopoⅡα低表达的特点与老年消化道肿瘤以高分化腺癌、大肠癌为主的临床病理特征有关。
Objective To investigate expressions of p53,P-glycoprotein（P-gp）,GST-π and TopoⅡα in old patients with gastrointestinal carcinoma.MethodsThe expressions of p53,P-gp,GST-π and TopoⅡα in gastrointestinal carcinoma tissue from 33 old patients（≥60 years old）were detected by immunohistochemistry,and 35 patients（〈60 years old）were selected as control group simultaneously.ResultsThere were significant differences in clinicopathologic features 〔well differentiated adenocarcinoma（22/33）and colorectal cancer ratios（22/33）〕 between the old patients and control group（all P〈0.01）.The expressions of P-gp and GST-π were significantly higher and TopoⅡα lower than those of control group（P= 0.009 1,0.026 and 0.032）.There was no difference in expression of p53 between old patients and control group（P=0.293）.ConclusionsThere are higher expressions of P-gp,GST-π and lower expression of TopoⅡα in old patients with gastrointestinal carcinoma,which is relevant to their clinicopathological features of high well differentiated adenocarcinoma and colorectal cancer ratios.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2009年第7期850-852,共3页
Chinese Journal of Gerontology
基金
河北省科技攻关计划项目(05276164)
关键词
消化道肿瘤
多药耐药性
老年人
Gastrointestinal carcinomas
Multidrugs resistance（MDR）
Elderly
