摘要
目的研究食管癌端粒酶活性与临床相关性。方法测定了４７例食管癌标本和２０例正常食管组织的端粒酶活性。结果３０例食管癌标本端粒酶活性阳性，约占８３％。对照组２０例正常食管组织，无１例阳性。邻近食管组织１７例，３例阳性，约占１７６％。不同临床分期和癌分级所表现的端粒酶活性也不同。在所送检的淋巴结有转移的１２例中，食管癌端粒酶活性均表现为阳性。结论食管癌病人有较高的端粒酶活性，端粒酶在食管癌发生、发展中起着重要作用。
Objective Our intent is to study the relevance between telomerase activity and clinical pathology in esophageal carcinomaMethods The telomerase activity was tested in 47 cases of esophageal carcinoma and 20 cases of normal esophageal tissue as a controlResults The results indicated that 39 of the 47 cases in esophageal carcinoma group and 3 of the 17 cases of the tissues adjacent to the carcinoma showed telomerase activity positive,accounting for 83% and 176% respectivelyIn all the 12 samples with metastasis to lymph nodes,telomerase activity was detectedConclusion The telomerase showed high activity and played an miportant role in developing esophageal carcinoma
出处
《济宁医学院学报》
1998年第1期1-3,共3页
Journal of Jining Medical University
关键词
食管癌
端粒酶
活性
病理
Esophageal
Carcinoma
Telomerase
