摘要
AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique.RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCLUSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,
AIM:To investigate the prognostic significance of phosphatase regenerating liver 3(PRL-3)protein expression in gastric cancer.METHODS:PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry.Monoclonal antibody specifically against PRL-3,3B6,was obtained with hybridoma technique.RESULTS:Positive PRL-3 expression was detected in 43.3%(127 of 293)of gastric cancer cases.High expression of PRL-3 was positively correlated with tumor size,depth of invasion,vascular/lymphatic invasion,lymph node metastasis,high TNM stage and tumor recurrence.Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression(28.3%vs 51.9%,P<0.0001).Patients who received curative surgery,and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression(hazard ratio of 16.7 and 16.6,respectively;P<0.0001 for both).Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients,particularly for survival in TNM stageⅢpatients.CONCLUSION:PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection.
基金
Supported by Grant for Key Technology Research and Development Program 2002BA711A06
National Basic Research Priorities Program 973 Project 1998051203
the Ministry of Science and Technology of China,and grant H020920030390,from the Beijing Science and Technology Commission
