摘要
本文用Ａｍｅｓ试验，微核试验和精子畸形试验对奥扎格雷钠的致突变作用研究，结果表明：①ＯＫＹ－０４６剂量为００５、０５、５、５０、５００μｇ／皿，进行Ａｍｅｓ试验，表明该药未能诱导ＴＡ９８、ＴＡ１００、ＴＡ１０２的回变菌落数增加（ＭＲ〈２）②ＯＫＹ－０４６药物剂量为３０６２ｍｇ／ｋｇ，６１２４ｍｇ／ｋｇ，１２２４８ｍｇ／ｋｇ时，均不诱发小鼠骨髓嗜多染红细胞的微核率增加。③ＯＫＹ－０４６药物剂量为２４５ｍｇ／ｋｇ，４９０ｍｇ／ｋｇ，９８０ｍｇ／ｋｇ时，均不诱发小鼠精子畸形率的增加。因此。
This paper reported the results of mutagenesis of sodium ozagrel OKY-046 assayed with the Salmonella mutagenicity test Ames test , micronucleus test of polychromatic erythroblast on mouse bone marrow and aberration of sperm test. The results showed that from 0.05-500μg/plate, OKY-046 didn't reduce the reversion frequencies in strain TA98, TA100 and TA102; OKY-046 couldn't increase the frequency of micronucleus at the doses of 306.2mg/kg, 612.4mg/kg and 1224.8mg/kg;OKY-046 didn't also increase the aberration rate of sperm at the doses of 245mg/kg, 490mg/kg and 980mg/kg, therefore, it is believed that OKY-046 may be safe on potential mutagenesis.
出处
《癌变．畸变．突变》
CAS
CSCD
1998年第2期113-115,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
微核试验
精子畸形试验
致突变性
奥扎格雷钠
sodium ozagrel
micronucleus
Salmonella mutagenicity test
aberration of sperm test
mutagenesis
