摘要
目的观察在胆囊腹腔镜手术中联合应用氟比洛芬酯与阿扎司琼的临床效果。方法45例择期行胆囊腹腔镜手术患者均采用全凭静脉麻醉,根据辅助用药的不同随机分为三组:联合应用氟比洛芬酯与阿扎司琼组(FA组,n=15);氟比洛芬酯组(F组,n=15);阿扎司琼组(A组,n=15)。FA组与F组诱导前和手术结束前15min分别静脉给予氟比洛芬酯1mg/kg,另外FA组手术结束前15min静脉给予阿扎司琼10mg;A组手术结束前15min静脉给予阿扎司琼10mg。术后用视觉模拟评分法(visual analogue scales,VAS)评估患者完全清醒时,术后0.5、2、6、12、24h的疼痛感觉程度,并观察各组苏醒期躁动、术后咽喉部疼痛不适及恶心、呕吐等不良反应发生情况。结果FA组和F组术后疼痛明显轻于A组,FA组和A组术后恶心呕吐率明显低于F组。结论氟比洛芬酯与阿扎司琼联合应用于腹腔镜胆囊切除术可在较长时间内明显改善术后的疼痛和减少恶心呕吐等不良反应。
Objective To study the effect of Flurbiprofen axetil combined with Azasetron in patients undergoing laparoscopic cholecystectomy （LC）. Methods Forty-five patients scheduled for LC with total intravenous general anesthesia were randomly assigned to 3 groups： Flurbiprofen axetil combined with Azasetron group （group FA, n=15）; Flurbiprofen axetil group （group F, n=15） and Azasetron group （group A, n=15）. Before the analgesic induction and 15 minutes before the end of surgery, patients in group FA and group F were intravenously injected with Flurbiprofen axetil 1 mg/kg respectively. Fifteen minutes before the end of surgery, patients in group FA were also intravenously injected with 10 mg Azasetron. Patients in group A were intravenously injected only with 10 mg Azasetron. VAS scores at the end of surgery and 0.5, 2, 6, 12, 24 hours after surgery were recorded individually. The incidence rate of restless, nausea and vomiting after surgery were recorded. Results VAS scores at 0.5, 2, 6, 12, 24 hours after surgery in group FA, group F and group A were no difference （P〉0.05）. The incidence rate of pain in group FA and group F were significantly lower than that in group A （P〈0.05）. The incidence rate of nausea and vomiting in group FA and group A were significantly lower compared with group F （P〈0.05）. Conclusion Flurbiprofen axetil combined with Azasetron can reduce the adverse reactions, such as pain, nausea and vomiting, in patients undergoing LC in more time.
出处
《肝胆胰外科杂志》
CAS
2009年第2期136-138,共3页
Journal of Hepatopancreatobiliary Surgery
基金
温州市科技局资助项目(Y2006A024)
关键词
胆囊切除术
腹腔镜
氟比洛芬酯
阿扎司琼
镇痛
cholecystectomy, laparoscopic
Flurbiprofen axetil
Azasetron
analgesia
