摘要
The effect of high dose dexamethasone(5 mg/kg wt,intravenous injection)to preventand treat secondary pathological damage due to craniocerebral injury was studied in an animal modelof craniocerebral injury caused by high-velocity missiles in dogs.We observed the physiologicalchanges,analyzed the level of serum and cerebrospinal fluid lactate dehydrogenase,cstimated thepermeability of blood brain barrier(BBB)and studied brain pathology by light and electronmicroscopy.The rusults suggest that high dose dexarnethasone can help to restore the structure andfunction of BBB,protect the brain cells,lessen the secondary pathological damage in the respiratoryand circulatory systams,and reduce the production of lipoperoxides(LPO).
The effect of high dose dexamethasone(5 mg/kg wt,intravenous injection)to prevent and treat secondary pathological damage due to craniocerebral injury was studied in an animal model of craniocerebral injury caused by high-velocity missiles in dogs.We observed the physiological changes,analyzed the level of serum and cerebrospinal fluid lactate dehydrogenase,cstimated the permeability of blood brain barrier(BBB)and studied brain pathology by light and electron microscopy.The rusults suggest that high dose dexarnethasone can help to restore the structure and function of BBB,protect the brain cells,lessen the secondary pathological damage in the respiratory and circulatory systams,and reduce the production of lipoperoxides(LPO).
