摘要
the effects of exogenous Na -DL- 3 - hydroxybutyratc (3- HOBNa) and insulin (I)on skeletal muscle protein metabolism in rats infected with 37% TBSA full thickness scald werestudied. It was found that the serum acetoacetatc (AcAc) of the burned animals showed nosignificant difference from the control on the 4th day postburn. but the free fatty acid (FFA) de-ereased markedly and the urinary 3 - methylhistidine (3 - MH ) excretion and the protein degrada-tion rate of the soleus muscle of the injured hind limb increased markedly. Infusion of3 - HOBNa for 3 consecutive days following bums could lower the urinary 3 - MH excretion andthe protein degradation rate of the soleus muscle with no significant influence on the skeletal muscleprotein anabolism. Moreover, investigations revealed that there was no synergistic effect ofinsulin -ketonc body combination on the anti- catabolic capacity in burned rats.
the effects of exogenous Na -DL- 3 - hydroxybutyratc (3- HOBNa) and insulin (I) on skeletal muscle protein metabolism in rats infected with 37% TBSA full thickness scald were studied. It was found that the serum acetoacetatc (AcAc) of the burned animals showed no significant difference from the control on the 4th day postburn. but the free fatty acid (FFA) de- ereased markedly and the urinary 3 - methylhistidine (3 - MH ) excretion and the protein degrada- tion rate of the soleus muscle of the injured hind limb increased markedly. Infusion of 3 - HOBNa for 3 consecutive days following bums could lower the urinary 3 - MH excretion and the protein degradation rate of the soleus muscle with no significant influence on the skeletal muscle protein anabolism. Moreover, investigations revealed that there was no synergistic effect of insulin -ketonc body combination on the anti- catabolic capacity in burned rats.
