摘要
党参是益气健脾代表中药,采用党参复方制剂治疗消化性溃疡脾虚证患者有较好疗效。脾可理解为以消化系统为主的多系统器官的功能综合单位。那么,党参的“健脾”作用以及党参复方制剂治疗消化性溃疡的作用途经与机制是否与影响胃粘膜防御机能有关?为此,我们采用建立大白鼠胃粘膜损伤性模型的方法,观察党参粗制剂及其有效成分的抗胃粘膜损伤作用,并进一步研究其作用机制。
This paper has reported that the pharmacological effects of the decoction of CP on preventing the gastric mucosal camage caused by alcohol, 0.6N HCI and 0.2N NaOH in rats. In the alcohol,0.6N HCI and 0.2N NaOH gastric mucosal damage models,the gastric mucosal damage indexes in pretreated groups of CP are respectively 0 + 0 (n=10), 3.9+.05(n=10)and 0 + 0 (n=10), and the indexes in control groups of distilled water are respectively 55.6+1.7 (n=10), 131.0+33.0(n=10)and 90.9+36.2(n=10) . There are significant difference between the pretreated group and the control group. Furthermore, the effect can be partly blocked by administration of indomethacin. These results ment-ioned-above have given a evidance that CP has a good protective effect on gastric mucosa and the pharmacological effective pathways are probably related to postgralandins content in gastric mucosa.The further researches are undertaking.
出处
《中药药理与临床》
CAS
CSCD
1989年第2期11-14,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
广东省自然科学基金会资助
