摘要
作者以火焰原子吸收法测定了65例肝硬化患者与16例正常人血清锌、铜,血清锌分别为11.77±13.96与14.09±1.15μmol/L(P<0.01),铜分别为15.68±4.54与19.55±2.36μmol/L(P>0.05),铜/锌比值分别为1.45±0.68与1.36±0.21(P<0.01)。51例失代偿期与14例代偿期肝硬化患者血清锌分别为11.20±3.96与13.82±3.26μmol/L(P<0.05)。29例HBsAg^+与13例HBsAg^-患者者血清锌分别为10.88±3.79与14.10±4.79μmol/L(P<0.02)。7例肝昏迷患者血清锌为10.15±2.33μmol/L,与14例代偿期肝硬化患者差异显著(P<0.02),并发现随着血清白蛋白的下降,血清锌有下降的趋势。
Serum zinc content may represent the degree of c dificiency in patients with cirrhosis. a compari- is made in this paper about the changes of serum c and copper content between 65 cirrhosis patients 1 16 healthy volunteers; and the clinical significance also discussed. All the patients, 58 males and 7 females, aged m 17 to 65 years, conformed with the diagnostic eria stilulated at Tianjin Meeting in 1964 Over- ht fasted serum was diluted ten times in 6% utanol, and zinc and copper levels were measured h an American ICP/5500 spectrum antlyser (flame thod). The zinc level in the serum of patients with er cirrhosis and healthy volunteers was 11.77±3.96 d 14.09±1.15 μmol/L respectively (P<0.01); the per level 15.68±4.54 and 19.55±2.36 μmol/L 0.05); and the copper/zinc rntio 1.45±0.68 and 6±0.21 respectively (P<0.01). The serum zinc was 11.20±3.96 μmol/L in 51 decompensated patients- 13.82±3.26 μmol/L in 14 compensated patients (P<0.05), 10.88±3.79 μmol/L in 29 HBsAg^- patients and 14.21±4.79 μmol/L in 13 HBsAg^- patients (P<0.02). Besides, the serum zinc level was declining with the descrease of albumin. In short, in cirrhotic patients, the marked fall of serum zinc, the fewer changes of copper, and the rise of marked cop- per/zinc ratio, all these may be regarded as an index of liver cirrhosis. The marked lowering of serum zinc may be related to the degree of severity of liver cirrhosis.
出处
《继续医学教育》
1989年第2期75-77,84+100,共5页
Continuing Medical Education
