摘要
本文报道8种荧光素的衍生物的半数致死量:2,7——二氯荧光素LD_(50)为207.8mg/kg;二氯荧光素二乙酸酯LD_(50)为466.5mg/kg;荧光素二丙烯酸酯LD_(50)为489.9mg/kg;四碘荧光素LD_(50)为500.2mg/kg;二溴荧光素二乙酸酯LD_(50)为608.7mg/kg;荧光素顺丁烯二乙酸酯LD_(50)为979.4mg/kg;二溴二硝基荧光素二乙酸酯LD_(50)为1463.5mg/kg;四溴四氯荧光素二乙酸酯LD_(50)为1496.5mg/kg。
This article reports on acute toxicities of eight derivatives of fluorescein after iatraperitoneal iajection siagul arly in mice. We have calculated 50％ lethal doses of eight derivatives. Their 50％ lethal doses were as foll- ows: LD_(50) of 2, 7—dichlorofluorescein was 207.8mg/kg; LD_(50) of dichlorofluorescein diacetate was 466.5mg/kg; LD_(50) of ester of accylic fluorescein was 489.9mg/kg; LD_(50) of tetraiodofluorescein was 500.2mg/kg; LD_(50) of dibromofluorescein diacetate was 608.7mg/kg; LD_(50) of reaction product of fluoresce in with maleicanhydride was 979.4mg/kg; LD_(50) of dibromodinitrofluorescein diacetate was 1463.5mg/kg; LD_(50) of tetrabromotetrachlorogluorescein diacetate was 1496.5mg/kg. It may he concluded that the data showed the acute toxicitles of these derivatives of fluorescein were not large.
出处
《兰州大学学报（医学版）》
CAS
1989年第4期189-193,共5页
Journal of Lanzhou University（Medical Sciences）
