摘要
Ｔｈｅｓｉｇｎｉｆｉｃａｎｃｅｏｆｃｅｒｔａｉｎｆａｃｔｏｒｓｉｎｔｈｅｍａｌｉｇｎａｎｔｄｅｇｅｎｅｒａｔｉｏｎｏｆｆｉｂｒｏｃｙｓｔｉｃｄｉｓｅａｓｅｏｆｂｒｅａｓｔｓ．￥Ｊｉａｎｇ，Ｊｕｎ（姜军）；ＺｈａｎＸｉｎ＇ｅｎ（詹新恩）；ＧｕＣｈｅｎｇ...
The changes of certain factors in the degeneration of fibrocystic disease(FCD) through atypical hyperplasia (AH) to breast cancer (BC) were observed inpatients and in normal subjects as controls. It was found that it generally took 2- 10 years for FCD to transform into BC and 2- 7 years for AH to BC. The carcinogenic rate of FCD was 3.1%. In FCD patients there was an increase of plasma level of estradiol and prolactin,which can stimulate the epithelial cells of the breasts to proliferate. The DNA content and the ultrastructure of the epithelial cells with general proliferation in FCD were similar to those of normal breasts (NB) and no expression of tumor-related antigens was found,but those cells with AH,which developed on the basis of general proliferation,showed an increase of DNA and abnormal ultrastructures of the cell membrane and nucleus. The AH cells also showed an increase of estrogen receptors which were dependent on and sensitive to sex hormones in a greater degree than the normal cells. The expression of embryonic Y antigen and IAP-2 was found in some of the AH cells and the expression became more intense along with the progress of AH untill BC occurred. These changes occurred quite regularly in most of the cases. The findings suggest that the conversion from the degeneration of FCD to BC is a slow and continuous biological process. In some of the AH cells, the abnormal biological behavior of cancer tendency and the phenotypic changes are closely related to the development of BC. It is believed that the changes of DNA and other parameters can be used as objective signs to predicr the occurrence of BC.
