摘要
本文通过对１８０例肺心病人血液流变学、超氧化物岐化酶及血气、酸碱的检测。结果发现，急性发作期，缓解期血清中ＳＯＤ—１活性均明显高于正常对照组（Ｐ＜０．０１）。本研究提示（１）氧自由基可能参与了肺心病的病理、生理过程。（２）慢性肺心病急性发作期血清、全血ＳＯＤ－１的含量高低对于诊断病情和估计预后具有重要意义。（３）为ＳＯＤ－１作为肺心病的一种外源性的治疗药物提供了依据，可能对于减轻肺损伤，减少及预防并发症的发生，促进肺心病的逆转、提高治愈率、降低死亡率具有十分重要的意义。
In the articl detection of blood rhology, SOD, change of blood gas and PH was per- formed in 180 patients with pulmonary heart disease. Effect showed that serum SOD-1 actirty in a- cute stage of attack and remission stage(60 cases) rose apparently in comparison with that of normal conktrols (P<0. 01). Through the research it could be certificated that (I) it was possible that oxygen free radical invoved in pathological and physiological prossess of pulmonary heart disease. (II) it was very important that either serum or blood change of DOD-1 content in patients of acute stage of at- tack with chronic pulmonary heart disease would concern disease judgement and prognosis estimation. Our research made it possible that during treatment SOD- 1 became one of exogempis dncgs in patients with pulmonary heart disease. The research showed it possible too that SOD-1 acted in eas- ing lung damage ,decreasing and preveting complication advancing the disease reversion, increasing cure rate and decreasing mortality.
出处
《中国血液流变学杂志》
CAS
1995年第2期23-26,共4页
Chinese Journal of Hemorheology
