摘要
The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum tissues increased remarkably when rats were at near-convulsion ; by the time the rats developed convulsion,it had a significant increase in all brain areas observed. Intraperitoneal injection of CSH or intracerebroventricular injection of ASS could delay initial time of convulsion (ITC),prolong survival time (ST) and reduce severity of convulsion (SOC). These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygeninduced convulsion.
Ｃｈａｎｇｅｓｏｆｓｏｍａｔｏｓｔａｔｉｎｃｏｎｔｅｎｔｉｎｓｏｍｅｂｒａｉｎａｒｅａｓｏｆｒａｔｓｄｕｒｉｎｇｏｘｙｇｅｎ－ｉｎｄｕｃｅｄｃｏｎｖｕｌｓｉｏｎＨｕＣｈａｎｇｈｏｎｇ（胡长虹）；ＮｉＧｕｏｔａｎ（倪国坛）；ＨａｎｇＲｏｎｇｃｈｕｎ（杭...
