摘要
Shortage of allogenic donor heart remains a serious problem all over the world leading to an upsurge in the study of xenografic cardiac transplantation. This study, based on the cuff technique, modified the grafting procedure in some aspects and successfully established a model of cervical cardiac xenotransplantation from guinea-pig to rat. Of 112 xenografting procedures performed in this group, the success rate of operation was 98. 2%, with only 2 cases of operative failure. Mean survival of the xenografts was 14±5. 5 min. The result showed that the modified model is more available and reproducible with much less bleeding than the original model, thus providing a more practical and stable experimental model for studying the mechanisms of hyperacute vascular rejection and the prevention of rejection in discordant cardiac xenotransplantation.
Ａｎｉｍｐｒｏｖｅｄｍｏｄｅｌｏｆｈｅｔｅｒｏｔｏｐｉｃｃａｒｄｉａｃｘｅｎｏｔｒａｎｓｐｌａｎｔａｔｉｏｎｆｒｏｍｇｕｉｎｅａ－ｐｉｇｔｏｒａｔＺｏｕＬｉａｎｇｊｉａｎ（邹良建）；ＺｈａｎｇＢａｏｒｅｎ（张宝仁）；ＺｈｕＪｉａｌｉｎ（朱家麟）；Ｈａ...
