摘要
用KPTT法测定33例正常人和25例各型AL血浆PC:C,结果表明:AL血浆PC:C明显低于正常人(P<0.001)。AL中尤以明显出血症状组的PC:C降低更为显著。AL的出血常呈白血病性凝血酶血症。凝血酶消耗蛋白C,引起PC:C显著降低。
We determined the plasma protein C activity (PC : C) in 33 normal donors and 25 AL patients with KPTT method. The results showed that : PC : C in normal donors and in AL patients was 100. 9%±25. 3% ( range 73. 0% to 145. 9% ) and 51. 7%±34. 5% (range 3. 5% to 152. 1%), respectively, and there was significant difference between the two groups (P<0. 001). In AL, PC : C in patients with noted bleeding decreased more significantly than in patients with no marked bleeding. (15. 3%±9. 3% VS 88.1%±59. 7% , P <0. 001). PC is a important anticoagulation factor which is a kind of vitamine K-dependent glycoprotein. AL patients with bleeding in many sites often developed leukemic thrombine-mia, the consumption of PC by thrombin caused fitorinolytec and coagnlation disturbance which aggravated bleeding.
出处
《血栓与止血学》
1995年第1期11-12,47,共3页
Chinese Journal of Thrombosis and Hemostasis
