摘要
为了探讨尿转铁蛋白（Tr）对早期糖尿病肾病的诊断价值，我们应用酶联免疫法测定了87例非胰岛素依赖型糖尿病患者尿中Tr、白蛋白（Alb）的含量，同时测定尿肌酐（Cr）、尿－N－乙酰－β－D－氨基葡萄糖苷酶（NAG）、尿β2－微球蛋白（β2－MG）、血肌酐及血尿素氮。结果显示：在糖尿病不同阶段，尿Tr／Cr均较正常增多；尿Tr／Cr的增高早于尿Alb／Cr的增高。尿Tr／Cr与尿Alb／Cr、尿NAG／Cr、尿β2－MG呈正相关，与血肌酐、血尿素氮呈正相关。说明尿Tr／Cr可反映糖尿病早期肾小球的损害，较Alb／Cr更为敏感，尿Tr／Cr可作为诊断早期糖尿病肾病的敏感指标。
To study the diagnosis value of transferrinuria for the eary diabetic nephropathy , we measured the concetration of transferrin (Tr), albumin (Alb) and creatinine (Cr) in the urin from 87 non - insulin-dependent diabetic patients by use of the ELISA and Jaffe reaction . The patients were divided into three groups according to their protein urine. The urine Tr/Cr ratio in all three groups was significanfly higher than that of the control group . The abnomality of the urine Tr/Cr ratio appeared earlier than Alb/Cr . The urine Tr/Cr ratio related positively with urine Alb/Cr, urine N - acedtyl - beta - D - Glucosamindase /Cr (NAG/Cr) and urine beta 2 - microglobulin (β2 - MG). The urine Tr/Cr ratio also related positively with serum creatinine and blood urea nitrogen . We conclude that the urinary Tr/Cr can reflect the glomerular damage in the early diabetic nephropathy and is more sensitive than urinary Alb/Cr. The urinary Tr/Cr is a sensitive indicator of the diagnosis for the eary diabetic nephropathy .
出处
《广州医学院学报》
1997年第1期77-79,82,共4页
Academic Journal of Guangzhou Medical College
关键词
转铁蛋白
糖尿病肾病
白蛋白
诊断
Transferrin
Diabetic Nephropathy
Albumin
Diagnosis
