摘要
肝源性 NO 可通过调节肝脏的微循环和 cGMP 的浓度来调节肝血流,并通过抑制细胞线粒体功能和某些核酸酶活性、抑制蛋白质合成以及参与肝脏的氧化损害过程等途径发挥细胞保护与细胞损伤的双重效应,在肝脏疾病的发生、发展与转归过程中具有极其重要的作用。
Nitric oxide(NO),a potent and highly versatile molecule in a variety of tissues,played a role in signal transduction,cell protection.intrinsic formation of cellula injury,and cell metabolism.A great deal of experiments on the No had been performed sinceBillar's first report concerning with that NO was synthesized from L—arginine in hepa-tocytes.No is catalyzed from L—arginine in Kupffer cell,endothelium of hepatic sinusoidand fat—storing cell(Ito cell)by two types of nitric oxide synthase(NOS),constitutiveNOS(cNOS)and inducible NOS(iNOS).No from liver modulates the microcirculationin liver and inhibits the mitochondrial function,RNase activity and protein synthesis inhepatocytes.NO may be concerned with a variety of liver diseases.
出处
《河北北方学院学报（自然科学版）》
1997年第3期41-47,共7页
Journal of Hebei North University:Natural Science Edition
