摘要
本文报道二氟尼柳原料药的高效液相色谱测定法。固定相为YWG-ODS,甲醇-水-乙腈-冰醋酸(50:35:17:2)为流动相,检测波长254nm,内标物为对羟基联苯。线性范围:2~400μg·ml(r=0.9999),回收率为99.07%,测定结果与英国药典法一致。
A HPLC method has been developed to determine diflunisal bulk Pharmaceuticals. Detected at 254nm,the analysis was carried out on DDS column using MeOH : H2O : CH3CN:Glacial HAC (50 :35:17 :2) as the mobile phase and p-hydroxyldiphenyl as the internal standard. The linear range was 2-400μg·ml (r = 0. 9999). The recovery was 99. 07%.
出处
《药学与临床研究》
1998年第1期16-17,共2页
Pharmaceutical and Clinical Research