摘要
目的:观察黄芩甙对大鼠感染性脑水肿的防治作用并探讨其作用机理。方法:采用左侧颈内动脉注射百日咳菌液诱发大鼠感染性脑水肿模型,研究黄芩甙对该模型脑水肿程度、脑组织铁含量、丙二醛(MDA)浓度和超氧化物歧化酶(SOD)活性的影响。结果:黄芩甙能明显减轻脑水肿程度(P<0.01),降低脑组织铁含量和 MDA 浓度(P<0.01),提高 SOD活性(P<0.01)。结论:黄芩甙对大鼠感染性脑水肿有治疗作用,其机理与抑制铁依赖脂质过氧化和保护 SOD 活性有关。
Objective:To observe the effects and mechanisms of the baicalin on the infective brain edema in rats.Methods:The infective brain edema model was induced by the injection of pertussis bacilli suspension into the left internal carotid artery of the rats.The effects of the baicalin on brain edema and iron content,malondialdehyde(MDA)level and superoxide dismutase(SOD)activity of brain tissue in the model were studied.Results:The baicalin could reduce the infective brain edema,and lower iron content,MDA level,and improve the activity of SOD.Conclusions:The baicalin possesses the protective effect on the infective brain edema in rats.The mechanisms were considered to be related with the inhibition of iron-dependent lipid peroxidation and the increased of SOD activity.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第S1期71-73,364,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
湖南省中医管理局资助课题
关键词
黄芩甙
感染性脑水肿
大鼠
铁依赖脂质过氧化
baicalin
brain edema
pertussis bacilli
iron-dependent lipid peroxidation
