摘要
目的比较两种三联疗法（OCA：奥美拉唑＋克拉霉素＋阿莫西林7d方案；RTA：善得胃＋替硝唑＋阿莫西林14d方案）根除幽门螺杆菌（Hp）感染的疗法方法采用随机对照临床试验设计，经内镜检查，快速尿素酶试验和病理检查证实有Hp感染的191例连续病例，通过随机化方法分为2组，A组接受OCA方案，B组接受RTA方案，连续随访6wk．随访结束时患者接受14C呼吸试验确定Hp根除率，部分溃疡患者经内镇检查确定溃疡愈合率.结果完成治疗及随访患者166例.两组的Hp根除率分别为84．2％和72．2％（P＞0．05）．两组中胃炎患者的Hp根除率分别为88．1％和71．0％（P＜0．05）．两组的溃疡患者的Hp根除率和溃疡愈合率的差异无统计学意义（79．4％vs75％，P＞0．05，80％vs75％，P＞0．05）B组方案发生的不适反应较A组多（n，80：52），但所有不适反应患者均能耐受.A组药物的医药成本较B组高（RMB，，820．78：418．04）．结论对于Hp相关性的胃炎患者，OCA方案虽然价贵，但根除率高，且不良反应少，而对于Hp相关性的溃疡患者，RTA方案和CCA方案疗效相当。
AIM To study the efficiency of triple therapy with 7-day omeprazole plus clarithromicin and amoxicillin (OCA)compared with 14-day ranitidine plus tinidazole and amoxicillin (RTA) for eradication of H. pylori (Hp)infecion.METHODS Endoscopically confirmed 191 consecutive petients with Hp infection (confirmed by urease test and pathology), were randrmly allocated into two groups,group A (OCA) and group B (RTA). Patients received either therapy and were followed up for six weeks. 14C urease test or endoscopy were used to test the eradication rate.RESULTS one hundred and sixty-six petients completed all the Study. The eradication rate were 84.2% in group A vs 72.2% in group B (P >0.05). The eradication rate of gestritis patients between the two groups were 88. 1% vs 71 .0% (P < 0.05 ). There was. no significant difference both of the Hp eradication rate and healing rate of the ulcer patients between the two groups (79. 4% vs 75%, P> 0.05, 80% vs 75%, P > 0.05 ). More side effects occurred in group B than in group A (n, 80: 52 ), which could be tolerated. The cost of group A is higher than that in group 8 (RMB, ,820.78 vs 418.04).CONCLUSION Considering the effedtiveness and cost,OCA therapy is more suitable for gastritis patients. For ulcer patients, RTA therapy is as efficacy as the OCA therapy.
出处
《世界华人消化杂志》
CAS
1998年第S2期202-204,共3页
World Chinese Journal of Digestology
