摘要
目的研究可注射性人胎盘胶原的理化性质及临床应用特点。方法将实验豚鼠随机分为两组,并将浓度为8mg/ml及30mg/ml的两种胶原分别注于两组豚鼠的皮下和皮内,以生理盐水作对照。实验鼠分别在注射后1、3、5、7、14、28、49、91、196天作大体观察和组织切片观察。结果显示可注射性人胎盘胶原不引起明显的过敏反应及炎症反应。注入宿主皮内后,能较长期稳定留存,并逐步被宿主的自身胶原替代,共同进入宿主的生命代谢过程。它还能使真皮的胶原纤维增加,真皮增厚,延缓了真皮的衰老。结论可注射性人胎盘胶原在整形美容外科中作为改善皮肤衰老中出现的皱褶及修复皮肤浅表凹陷性缺损具有实用价值。
Objective To investigate the physiochemical property and clinical application of the Injectable Human Placental Collagen (IHPC). Methods The experimental guinea pigs were divided into two groups at random. Two contents of IHPC (8mg/ml and 30mg/ml) were used by intradermal or subcutaneous injection in this two groups while saline was used as control. Microscopical and histological observation were performed 1, 3, 5, 7, 14, 28, 49, 91, 196 days after injection. Results The results revealed that IHPC didn't cause any allergic and inflammatory reaction. It could exist for a long time in the host after intradermal infection and be substituted gradually by host collagens, finally was mixed with the host. It can also increase the amount of collagen fibers in dermal and make the dermal thicker, result in postpone the ageing of the dermal. Conclusion IHPC has the practical value in cosmetic surgery for improving the wrinkles with skin ageing and repairing the pitting defect on the superficial skin.
出处
《组织工程与重建外科杂志》
2005年第4期225-226,201,共3页
Journal of Tissue Engineering and Reconstructive Surgery
