摘要
目的了解孕妇这一特殊人群乙肝病毒感染及免疫状况,为更好防治乙肝母婴传播提供科学依据。方法采用ELISA法检测4461例孕妇血清中HBsAg、HBsAb、HBeAg、HBeAb、HbcAb5项乙肝标志物,采用荧光定量PCR法对HBsAg阳性的孕妇血清进行HBV-DNA病毒载量检测,并对结果进行统计分析。结果4461例孕妇的乙肝抗原抗体系统出现了10种模式。5项标志物全阴为76.96%;HBsAb阳性率为13.70%;HBsAg阳性率为7.15%;"大三阳"阳性率为2.38%;"双阳"阳性率为0.11%;"小三阳"阳性率为2.62%。在319例HBsAg阳性的孕妇中,血清HBV-DNA中,高度复制者占52.98%。结论孕妇人群乙肝的免疫力明显低于其他人群,且其病毒复制水平远高于其他乙肝患者,提示应加强孕妇乙肝标志物筛查,发现患者并及时对初生婴儿注射乙肝免疫球蛋白和疫苗,遏制乙型肝炎的母婴传播。
Objective To know the situation of the Hepatitis B Virus'( HBV) infection and immune in the special group of pregnant women, and to provide scientific evidence for the prevention of mother-to-infant transmission of HBV. Methods ELISA method was used to test the five HBV marks which are HbsAg, HbsAb, HbeAg, HBeAb and HBcAb in the 4461 samples of pregnant women's blood serum and the method of fluorescence quantitative PCR was used to detect the HBV-DNA viral load of the pregnant whose HBsAg is positive. Results There appears to be 10 patterns of HBV antigen systems among the 4 461 pregnant women samples. The rate that all the five marks are negative is 76.96%.The rate of HBsAb is positive is 13.70%, HBsAg is 7.15%,'big triple positive' is 2.38% 'double positive'0.11%, 'little triple positive'is 2.26%. Among 319 HBsAg positives, the medium and highly duplication of blood serum HBV-DNA take part of 52.98%.Conclusion The immune level of the group of the pregnant wamen is lower than other people obviously, and the duplication level of the virus is higher than other HBV patients, which mentions that we should strengthen the screening of HBV marker in pregnant women, detect patients and inject immunoglobulin and vaccine of HBV to the infant in time to prevent the mother-to-infant transmission of HBV.
出处
《中国社会医学杂志》
2007年第4期284-286,共3页
Chinese Journal of Social Medicine
