摘要
【目的】研究非小细胞肺癌(NSCLC)患者放疗前、放疗过程中和放疗后IL-1α和IL-6的变化,探讨它们在放射性肺炎发生中的作用。【方法】2005年7月-2005年12月因NSCLC行立体定向放射治疗,且放疗后随访9个月以上的患者48例,根据放疗后是否发生放射性肺炎分为放射性肺炎组(A组)和无放射性肺炎组(B组),于放疗前、放疗过程中每周和放疗后8、12周清晨空腹采血3 ml,用双抗体夹心ELISA法测血清IL-1α和IL-6水平。【结果】血清IL-1α浓度A组患者在放疗前、放疗中各个时间点及放疗后均显著高于B组(P<0.01)。IL-6血清浓度在放疗过程中波动较大,且放疗结束后A组8周和12周IL-6浓度显著增高(A组与B组同时间点相比,放疗前和放疗后8周、12周P<0.01,放疗中各时间点P<0.05)。【结论】IL-1α和IL-6可作为放射性肺炎的早期预测指标。
[Objective] To investigate the effect of circulatory cytokines IL-la and IL-6 on radiation pulmonary injury. [Methods] Forty-eight patients with non-small-cell lung cancer （NSCLC） received three-dimensional conformal radiation therapy from July 2005 to December 2005, whose follow-up were over 9 months. Patients were divided to two groups according to their subse- quently developing radiation pneumonitis （group A） or not （group B） . Blood samples were taken before, during radiation and up to 12 weeks after-radiation. The IL-1α and IL-6 concentration was measured before, during and after radiation treatment using a double antibody sandwich enzyme-llnked immunosorbent assay kit. [Results] IL-1α levels were significantly higher before radiation, at multiple time points during radiation, and after radiation for those who developed pneumonitis （ P 〈 0.01 ） . IL-6 levels fluctuated somewhat with radiation, and after eompletion of radiation treatments eight weeks or twelve weeks, there was a trend toward an increase of IL-6. [ Conclusions] IL-1α and IL-6 levels may be used as a parameter for predicting the risk of radiation pneumonitis before or during the early stage of therapy.
出处
《武警医学院学报》
CAS
2009年第3期194-196,共3页
Acta Academiae Medicinae CPAPF
