摘要
目的:采用海南青牛胆茎提取物,通过对小鼠急性毒性实验及安全性研究,作出初步评价。方法:取KM小鼠50只,雌、雄各半,10只做预试验,另40只按同性别随机分为雌、雄空白对照组(蒸馏水组)和药物组,每组各20只。对小鼠空腹经口灌胃给予青牛胆提取物分别为人临床用量的200倍、400倍和600倍剂量,观察小鼠出现的毒性反应及有无死亡。结果:观察7 d,未见小鼠死亡,所有受试小鼠毛色光洁,活动、饮食和二便正常,两组经t检验,差异无统计学意义(P>0.05)。结论:海南青牛胆未见有明显毒性反应,表明本品安全性较高。
Objective： To evaluate the safety of tinospora hainanensis. Methods： 200, 400 and 600 times of clinical dosage of tinospora hainanensis extraetion were administered to rats by intragastrie administration. Acute toxicity reactions and death were recorded. Results： During 7 days of administration, all rats ate, and discharged normally, kept normal figure and movement. No death was observed. There is no significant difference between the dispersing liver and improving eye-sight and the distilled water group （P 〉 0.05 ）. Conclusion： No obvious toxicity reactions were observed and tinospora hainanensis is pretty safe.
出处
《海南医学院学报》
CAS
2009年第4期306-307,310,共3页
Journal of Hainan Medical University
基金
海南自然科学基金资助项目(批准号30628)
关键词
青牛胆
提取物
急性毒性实验
海南省
Tinospora hainanensis
Extraction
Acute toxicity test
Hainan Province
