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噻唑烷二酮类药物在皮肤病临床应用进展 被引量:1

Thiazolidinediones in dermatology
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摘要 噻唑烷二酮类(TZDs)如罗格列酮等是治疗2型糖尿病的新降糖药,其作用靶点是过氧化物酶体的增殖活化受体PPARγ。TZDs刺激脂肪细胞分化,增强肌肉、脂肪细胞胰岛素敏感性,减少血管并发症,抑制肿瘤细胞生长,使皮肤角质层细胞的分化趋向正常化;还能减少炎性细胞因子、肿瘤坏死因子-α产生。现有临床研究表明,TZDs对银屑病、多毛症、黑素瘤、血管肉瘤、皮下脂肪萎缩和类脂质渐进坏死等多种皮肤病治疗有效。
作者 张晓菲 郝飞
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2009年第4期267-269,共3页 Journal of Clinical Dermatology
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