摘要
乙酰丹酚酸Ａ对血小板花生四烯酸代谢的影响吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）在体内外能明显抑制花生四烯酸（ａｒａｃｈｉｄｏｎｉｃａｃｉｄ，Ａ...
Acetylsalvianolic acid A (ASAA) has been shown to be an antiplatelet compound. Our studies with RIA showed that: at the dosage of inhibiting platelet aggregation, ASAA was found to inhibit the formation of cyclooxygenase pathway metabolites TXB2 in platelets. In addition, ASAA was also shown to promote the formation of 6ketoPGF1α in rabbit aortic rings in vitro. The above results suggest that ASAA may inhibit the proaggregator TXA2 formation, promote mildly the antiaggregator PGI2 generation and probably, whereby, exert its antiplatelet activity.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第1期62-63,共2页
Acta Pharmaceutica Sinica
关键词
乙酰丹酚酸A
血小板
花生四烯酸
代谢
Salvia miltiorrhiza
Salvianolic acid
Arachidonic acid
Thrombaxane A2
Acetylsalvianolic acid A
