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羊水脱落细胞中c—myc基因检测在诊断葡萄胎中的意义 被引量:1

Diagnosis Significance of c-myc mRNA in Amniotic Fluid Cast-off Cells for Hydatidiform Mole
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摘要 目的研究羊水脱落细胞中c—mycmRNA的检测在葡萄胎的诊断意义.方法以53例健康妊娠女性为对照,采用RT—PCR检测50例良性葡萄胎患者和48例恶性葡萄胎患者羊水脱落细胞中c—mycmRNA的表达.结果健康组女性阳性率为5.7%(3/53),良性葡萄胎患者阳性率为26%(13/50),恶性葡萄胎患者阳性率为75%(36/48),三者之间差异有统计学显著性意义(P〈0.05或P〈0.01).结论检测羊水脱落细胞中c—mycmRNA的表达有助于恶性葡萄胎的诊断,对良性葡萄胎的诊断也有一定的参考意义. Objective To investigate the diagnosis significance of c-myc in amniotic fluid cast-off cells for hydatidiform mole. Methods C-myc mRNA in amniotic fluid cast-off cells from 50 patients with nonmalignant hydatidiform mole and 48 patients with malignant hydatidiform mole was detected by RT-PCR and 48 healthy pregnant females were also analyzed as healthy control. Results In healthy pregnant females,the positive ratio of c-myc mRNA was 5.7% (3/53),in the patients with nonmalignant hydatidiform mole,the positive ratio was 26(13/50),and in the patients with malignant hyda- tidiform mole,the positive ratio was 75%(36/48). The difference among healthy pregnant females,patients with nonmalignant hydatidiform mole and patients with malignant hydatidiform mote was significant. Conclusion C-myc mRNA in amniotic fluid cast-off cells is a potential reference marker of malignant hydatidiform mole,and the detection for the marker can also help diagnose nonmalignant hydatidiform mole.
出处 《现代检验医学杂志》 CAS 2009年第2期88-90,共3页 Journal of Modern Laboratory Medicine
关键词 羊水脱落细胞 c—myc MRNA 葡萄胎 amniotic fluid cast-off cells c-myc mRNA hydatidiform mole
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