摘要
目的研究垂盆草提取液对实验性急性肝损伤小鼠免疫和抗氧化功能的影响。方法通过注射环磷酰胺(CP)抑制小鼠的免疫细胞,达到降低淋巴细胞增殖水平和网状内皮系统的吞噬功能,观察药物对小鼠免疫功能的调节作用;给小鼠注射D-半乳糖(D-gal),造成实验性急性肝损伤模型,测定血清及肝脏中超氧化物歧化酶(SOD)活力和丙二醛(MDA)浓度,观察垂盆草提取液对小鼠抗氧化能力的影响。结果垂盆草提取液能明显促进免疫抑制状态小鼠的淋巴细胞增殖及网状内皮系统的吞噬功能,垂盆草提取液对D-gal所致小鼠急性肝损伤模型具有提高SOD活性和降低MDA浓度的作用。结论垂盆草提取液对免疫功能低下的小鼠具有增强作用,同时能提高实验性肝损伤小鼠的抗氧化能力。
Objective To investigate the immune and antioxidative effect of Sedum sarmentosum Bunge Exract on experimental acute hepatic damage in mice. Methods Injection of cyclophosphamide（Cy） inhibited the immune cellular activity of mice,and phagocytic function of the reticulocndothclial and proliferation of lymphocytcs were depressed.The immunologic effects of the drugs was observed. Superexide dismetase（SOD） and malondialdehyde（MDA） of blood and liver were recorded in mice with injection of D--galactosidase induced acute hepatic damage,The antioxidative effects of the drugs was observed. Results Sedum sarmentosum Bunge Exract can enhance the proliferation of lymphocytes and the phagocytosis of the reticuloendothelial in mice with immunosuppression.And can enhance SOD activity,but lowered MDA concentrations. Conclusion Sedum sarmentosum Bunge Exract can enhance immuofuctions of immunosuppressed mice and increase antioxidative functions of mice with acute hepatic damage.
出处
《中外医疗》
2008年第31期19-21,共3页
China & Foreign Medical Treatment
关键词
垂盆草提取液
免疫调节
抗氧化功能
Sedum sarmentosum Bunge Exract
Immune Adjest
Antioxidative function
