摘要
目的:探讨单用脑蛋白水解物与联合使用单唾液酸四已糖神经节苷脂,治疗新生儿缺血缺氧性脑病的临床疗效。方法:随机分成两组。治疗组(联合使用脑蛋白水解物与单唾液酸四已糖神经节苷脂n=35);对照组(脑蛋白水解物治疗组n=30)。两组病人均在对症支持处理的基础上进行,观察比较两组患儿神经系统症状体征的恢复时间,HIE 临床,NBNA评分。结果:治疗组新生儿症状体征恢复时间明显较对照组缩短,P<0.01,差异有显著性,生后7～8天,10～14天NBNA评分治疗组分值高于对照组,P<0.05,差异有显著意义。结论:联合使用脑蛋白水解物与单唾液酸四已糖神经节苷脂治疗HIE,较单用脑蛋白水解物能显著缓解症状体征,缩短病程,减轻脑损伤,提高治愈率。
Objective：To investigate the curattive effect of GM - I combined with cerebroprotein hydrolysate on hypoxic - ischemie encephalopathy （HIE） in neonate . Methods：65 cases of neonatal hypoxlc - ischemic encephalopathy were divided randomly into observation group （ n = 35 ） and control group（n =30）. In addition to individualized supportive treatment, patients in control group were treated with cerebroprotein hydrolysate, patients in observation group were treated with ganglioside GM - I combined with cerebroprotein hydrolysate. The duration of recovery and the changes of neonatal behavior neurological assessment （ NBNA ） in the two groups were compared. Results： The recovery time of observation group was obviously shorter than that of control group with a singnificant difference （ P 〈 0. 01 ） ; Meanwhile postnatal NBNA at 7and at 14 in observation group were obviously higher than those of control group with a singnificant difference （ P 〈 0. 05 ）. Conclusion ： Combi- nation Ganglioside GM - Ⅰ with cerebrpro- tein hydyolysate therapy can improve clinic curative effect, lower duration of recovery, and reduce incidence of disability in neonates with HIE.
