摘要
目的：测定正常成人的肺弥散能力（ＤＬ）、肺泡毛细血管膜弥散能力（Ｄｍ）及肺毛细血管床容量（Ｖｃ），计算与年龄、身高、体重相关的回归方程；研究年龄对于ＤＬ特别是对Ｄｍ、Ｖｃ的影响以及后三者之间的关系。方法：单次呼吸法测定ＤＬＣＯ，测定不同吸入气氧分压下的ＤＬＣＯ，采用Ｒｏｕｇｈｔｏｎ和Ｆｏｓｔｅｒ方法计算Ｄｍ和Ｖｃ。结果：年龄与ＤＬ、Ｄｍ、Ｖｃ呈中度或高度负相关，ＤＬ与Ｄｍ和Ｖｃ、ＶＡ与ＤＬ、Ｄｍ和Ｖｃ中度或高度正相关；ＤＬ、Ｄｍ在４０岁以后开始降低，Ｖｃ在５０岁以后开始降低；在各年龄组ＤＬ、Ｄｍ和Ｖｃ的回归方程中，身高和／或年龄为进入公式的主要变量。结论：（１）年龄与Ｄｍ、Ｖｃ呈线性负相关；（２）Ｄｍ在４０岁以后开始降低，Ｖｃ减少发生在５０岁以后；（３）ＤＬ在４０岁以后随年龄增加而减少主要是由于Ｄｍ、Ｖｃ的降低所引起；（４）Ｄｍ、Ｖｃ的减少与ＶＡ随年龄变化有关；（５）身高和／或年龄是Ｄｍ。
Objective: Measuring pulmonary diffusing capacity (DL), alveolar capillary membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) in normal adults; calculating the regression equation correlated to age, height and body weight; evaluating the effect of age on Dm and Vc; studying the relationship among DL, Dm and Vc.Methods:Spirometry was performed in the sit position. Several measurements of diffusint capacity of the lung for carbon monoxide (DL CO) were taken by singlebreath method at increasing alveolar oxygen tension (PA O2). The estimations of Dm and Vc were done by the method of Roughton and Forster.Results:(1)There was a significant negative corelation between age and DLCO, Dm and Vc. The correlations between DL and Dm, Vc as well as VA and DL, Dm, Vc are significantly positive.(2)DL and Dm decreased after 40 and Vc decreased after 50. DL/VA Dm/VA and Vc/VA decrease after 60 years of age. There was no significant difference of Dm/Vc among groups. (3)Height and/or age were the main variables in stepwise multiple linear regression equations for DL, Dm AND Vc in all groups.Conclusion:(1)There is a significant negative correlation between age and DL, Dm and Vc.(2)DL and Dm decrease after 40 and Vc decrease after 50. Age has not a significant influnce on Dm/Vc.(3)The declining in DL may be due to the decrease of Dm and Vc. (4)The decrease of Dm may be related to the reduction of VA with age. (5)Height and/or age are the main variables in regression equations for DL, Dm and Vc.
出处
《军医进修学院学报》
CAS
1998年第2期132-134,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
血气屏障
肺毛细血管床
容量
肺泡
DM
VC
bloodair barrier
pulmonary capillary blood volume
age distribution
