摘要
目的 探讨65岁以上可手术女性乳腺癌患者的临床及病理特点。方法收集分析2003年2月至2005年2月收治的95例65岁以上可手术老年女性乳腺癌患者的临床和病理资料及其特征。结果全组95例65岁以上老年乳腺癌占同期外科住院治疗的乳腺癌的26．1％，从出现症状到就诊平均1．2年，74．5％为局部进展期肿瘤，67．4％合并其他疾病。主要病理类型为浸润性导管癌（67．3％），彤孕激素受体阳性率为68．4％，CerbB-2过表达比例为23．5％，Ki-67指数较低（〈30％者54．1％）。94例患者96侧乳房接受手术治疗，其中非根治性手术26例，71例接受化疗，67例接受内分泌治疗。3年总生存率为87．4％，无病生存率为71．4％。结论老年乳腺癌以局部晚期肿瘤居多，具有独特的生物学特征。宜选择创伤小的手术方式，辅以内分泌治疗和化疗等。
Objective To study the clinical and pathological characteristics of operable breast cancer in women over 65 years. Methods The data of 95 patients treated from February 2003 to February 2005 were collected, and the clinicopathological characteristics were retrospectively analyzed. Results These 95 patients accounted for 26. 1% of all female breast cancer patients registered in our hospital in the mean time. Local advanced breast cancer accounted for 74. 5% of the patients. The median time from symptom presentation to treatment seeking was 1.2 years. Curative resection was performed in 96 breasts of 94 patients, 71 patients received chemotherapy and 67 received endocrine therapy. Sixty-four cases （67.3%） were confirmed invasive duetal carcinoma. Positive expression of estrogen or progesterone receptor was found in 65 cases （68.4%） ; overexpression of C-erbB-2 was found in 23.5% of the patients and low level expression of Ki-67 （ 〈 30% ） was found in 54. 1% of the cases, respectively. The 3- year overall survival rate and disease free survival rate was 87.4% and 71.4% , respectively. Conclusions Of the breast cancer in aged women, most are local advanced breast cancer. Breast cancer in the elderly women has distinctive clinieopathological characteristics. Less radical surgery combined with adjuvant chemotherapy and （or） endocrine therapy is feasible treatment.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2009年第7期516-518,共3页
Chinese Journal of Surgery
关键词
乳腺癌
老年女性
临床
病理分析
Breast cancer
Elderly women
Clinical
Pathological feature
