摘要
目的探讨鼻腔局部应用糖皮质激素布地奈德(budisonide)对鼻息肉组织中COX-2表达的影响。方法采用免疫组织化学染色,观察比较经布地奈德喷鼻治疗10～12周鼻息肉组织(20例)和未治疗鼻息肉组织(20例)中COX-2蛋白的表达状况。结果治疗组COX-2表达率为25.0%,未治组COX-2表达率为85.0%,2组的表达率差异有显著性(P<0.05),治疗组鼻息肉组织中COX-2表达显著低于未治组。结论糖皮质激素可能通过抑制COX-2的表达而减少前列腺素生成,从而发挥其抗炎效应。
[Objective] To investigate the effect of intranasal glucocorticoids （budesonide） treatment on the expression of COX-2 nasal polyps. [Methods] Immunohistochemistry method was used to determine COX-2 expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks （n =20） and untreated patients （n =20）. [Results] The rate of COX-2 expressing cases was 25.0% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of COX-2 expressing cases was 85.0%. There were significant differences between two groups （P 〈0.05）. The COX-2 expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients. [Conclusions] The resuhs showed that glucocorticoids may reduce prostaglandins production to make antiinflammatory effect in nasal polyps by depressing the COX-2 expression.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第5期782-784,共3页
China Journal of Modern Medicine
