摘要
[目的]探讨早期子宫颈浸润鳞癌组织中环氧合酶-2(COX-2)表达的临床意义。[方法]采用免疫组化EnVision法检测158例子宫颈浸润鳞癌组织和100例正常宫颈组织中COX-2表达。[结果]早期子宫颈鳞癌组织COX-2阳性表达率为55.70%(88/158),明显高于正常宫颈组织(0/100)(χ2=84.527,P=0.000)。单因素分析显示宫颈癌组织COX-2的表达水平与临床分期、宫颈深间质浸润和脉管内瘤栓有关(P<0.05);与年龄、淋巴结转移、复发/转移、病理分化程度及肿瘤大小无关(P>0.05)。[结论]早期子宫颈鳞癌组织COX-2表达阳性者应慎重考虑术后辅助治疗方法。
[Purpose] To explore the clinical significance of cyclooxygenase-2（COX-2） expression in tumor tissues of 158 cases with early stage cervical squamous cell carcinoma. [Methods] Immunohistochemical assay （EnVision method） was used to detect COX-2 in all speeimens, includ- ing 158 invasive cervical squamous cell carcinoma and 100 normal cervices. [Results] The overall positive expression rate of COX-2 in cervical cancer （55.70%, 88/158） was higher than that in normal cervix（0/100）（X2=84.527 ,P=0.000）. In univariate survival analysis, positive COX- 2 expression related to staging, deep stromal invasion and lymph vascular space involvement （P〈 0.05）. The intensity of expression of COX-2 in cervical cancer did not relate to age, lymph node metastasis, occurrence/metastasis, tumor differentiation and tumor size（P〉0.05）. [Conclusionl Postoperative adjuvant treatment should be considered for the cases of COX-2 positive expres- sion with early stage cervical squamous cell carcinoma.
出处
《肿瘤学杂志》
CAS
2009年第3期185-187,共3页
Journal of Chinese Oncology
关键词
宫颈肿瘤
癌
鳞状细胞
环氧合酶-2
免疫组织化学
cervical neoplasm
carcinoma, squamous cell
cyclooxygenase-2
immunohisto- chemistry
