摘要
目的探讨抑郁症与Nogo基因的3端未编码区CAA Ins/Del(插入/缺失)突变的相关性。方法应用聚合酶链反应(PCR)及聚丙烯酰胺凝胶电泳(PAGE)方法,检测321例抑郁症患者和250名健康对照Nogo基因的CAA Ins/Del基因突变分布,采用SHEsis软件分析该基因多态性与抑郁症的关系。结果Nogo基因的3端未编码区CAA Ins/Del突变的基因型和等位基因频率在患者组和对照组间的差异无统计学意义(2=2.01,P>0.05;2=0.31,P>0.05)。结论未发现Nogo基因的3端未编码区CAA Ins/Del与抑郁症相关。
Objective To analysis the association between CAA 3＇UTR insertion/deletion polymorpbisms of the Nogo gene and major depression. Methods A total of 321 patients with depression and 250 control subjects were recruited in this study. The Nogo 3＇UTR CAA insertion/deletion genotypes were determined using PCR-polyaerylamide gel electrophoresis. Results No significant differences in Nogo 3＇UTR CAA insertion/deletion genotype and allele frequencies were ob- served between the patients with major depression and controls. Conclusions This study does not confirm an association of Nogo 3＇UTR CAA insertion/deletion polymorphism with major depression.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2009年第3期145-147,共3页
Chinese Journal of Nervous and Mental Diseases
基金
上海市科委重点项目(编号:06CJ4601)
